This episode explores how women’s hormones, aging, regenerative therapies, and technology are shaping the next era of longevity medicine. Dr. Amy Killen shares her evolution from ER doctor to multi-company entrepreneur, her work in stem cells and full-body regenerative procedures, and the role of diagnostics, AI, and hormone optimization in midlife women’s health. You’ll get an inside look at the queen phase of perimenopause, the future of longevity clinics, and how women can stay proactive as they age.

KEY TOPICS

• Estrogen, perimenopause and the queen phase of women’s midlife
• Dr. Killen’s shift from ER medicine to entrepreneurship in longevity
• Stem cells, exosomes and whole-body regenerative therapies
• Reputable Health, Hop Box and Humanát Health’s tech-enabled clinical model
• AI-driven care plans, advanced diagnostics and the future of preventive longevity care
• TIMESTAMPS

[00:00 ] Estrogen as a forgotten longevity drug and the mental health impact of perimenopause

[00:56 ] Show intro and framing women’s health, resilience and personal transformation

[01:27 ] ER burnout, single motherhood and the moment everything shifted

[03:23 ] Leaving the ER and confronting criticism around hormones and regenerative medicine

[04:08 ] Partnering with Docere Clinics and developing the Full Body Stem Cell Makeover

[06:33 ] Stacking stem cells, exosomes, peptides, light therapy and sound therapy

[08:10 ] Transformations in pain, sexual health and functional recovery using stem cells

[10:09 ] Musculoskeletal outcomes and delaying joint replacement surgeries

[10:57 ] Skin quality improvements, subtle rejuvenation and hair restoration in women

[13:33 ] Stem cells vs PRP and when each modality is most effective

[13:51 ] Founding Reputable Health to modernize clinical trials using wearables

[15:11 ] How biohackers join studies and test real supplements and devices

[16:28 ] Using AI to extract insights from sleep, HRV and wearable data

[16:57 ] Creating Hop Box as a simple, evidence-based female longevity stack

[18:17 ] Supplements tailored to female physiology, insulin resistance and skin health

[19:29 ] Why Hop Box is not a multivitamin and how ingredients like spermidine fit in

[21:06 ] Defining the queen phase and why women lose hormonal protection

[23:11 ] Men’s gradual testosterone decline vs women’s hormonal cliff in midlife

[24:52 ] Stress load in midlife and why so many women struggle in their 40s and 50s

[25:43 ] Hormone therapy as a foundational pillar for women’s longevity

[26:18 ] Building Humanát Health as a next-gen longevity clinic franchise

[28:21 ] Core pillars of longevity care: lifestyle, diagnostics and prevention

[30:39 ] Comparing Humanát to other longevity and biohacking clinics

[32:36 ] Evidence-based hormone protocols and training providers at scale

[35:31 ] How Humanát uses advanced diagnostics and AI-generated care plans

[39:45 ] Why the franchise model expands access to longevity medicine

[42:54 ] Membership tiers, affordability and the future of nationwide rollout

[43:41 ] Inside the Humanát gym: VO2 max, strength, balance and kinetic testing

[44:34 ] Advice to clinicians entering longevity entrepreneurship

[45:42 ] The next decade of regenerative medicine and the role of women

[46:41 ] Balancing motherhood, procedures, multiple companies and travel

[47:45 ] Where to find her clinics, supplements and platforms

[49:14 ] Closing reflections on the women’s longevity revolution

Guest: Dr. Amy Killen

Website: https://dramykillen.com/

Instagram: https://www.instagram.com/dr.amybkillen/

LET’S CONNECT

Host: Orshi McNaughton

Podcast: https://optimized-women.captivate.fm/listen

Website: https://www.optimizedwomen.com/

YouTube: https://www.youtube.com/@optimizedwomen

Instagram: https://www.instagram.com/orshimcnaughton

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